sporozoites and glycolipid adjuvants

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United States of America Patent

PATENT NO 9278125
APP PUB NO 20140120138A1
SERIAL NO

14065012

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Abstract

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Disclosed herein are pharmaceutical compositions comprising Plasmodium sporozoite-stage parasites and compatible glycolipid adjuvants useful in vaccines for preventing or reducing the risk of malaria. In particular, human host range Plasmodium and analogues of α-galactosylceramide (α-GalCer), a ligand for natural killer T (NKT) cells, are combined in pharmaceutical compositions, which are useful as vaccines against malaria. Methods of use are also provided.

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Patent Owner(s)

Patent OwnerAddress
THE ROCKEFELLER UNIVERSITY1230 YORK AVENUE NEW YORK NY 10065

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chakravarty, Sumana Derwood, US 5 31
Hoffman, Stephen L Gaithersburg, US 40 483
Tsuji, Moriya New York, US 19 410

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