Polymeric drug delivery conjugates and methods of making and using thereof
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United States of America Patent
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Mar 22, 2016
Grant Date -
Jun 20, 2013
app pub date -
Mar 7, 2011
filing date -
Mar 8, 2010
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Abstract
Described herein are biodegradable drug delivery conjugates for effectively delivering bioactive agents to a subject. The drug delivery conjugates comprise a water-soluble high molecular weight linear biodegradable polymer backbone comprising a plurality of linear water-soluble polymeric segments connected to one another by a first (main-chain) cleavable linker, wherein a bioactive agent is covalently bonded to at least one water-soluble polymeric segment, at least one cleavable linker, or a combination thereof. The conjugates possess numerous advantages over prior art delivery conjugates. Also described herein are methods for making and using the conjugates.
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