Carbonic anhydrase inhibitors and method of their production

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United States of America Patent

PATENT NO 9290529
APP PUB NO 20140303390A1
SERIAL NO

14352210

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Abstract

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Derivatives of boron cluster compounds of general formula I and their pharmaceutically acceptable salts and solvates, and their specific inhibition effect on the enzyme carbonic anhydrase IX, a protein overexpressed in cancer tissues. Methods of synthesis and the use of the novel derivatives. These inhibitors of human carbonic anhydrase IX can be used as active compounds of pharmaceuticals for diagnostics and/or therapy of cancer diseases.

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Patent Owner(s)

Patent OwnerAddress
UNIVERZITA PALACKEHO V OLOMOUCI779 00 OLOMOUC
USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CESKE REPUBLIKY V V I166 10 PRAHA 6
USTAV ANORGANICKE CHEMIE AKADEMIE VED CESKE REPUBLIKY V V IREZ 1001 HUSINEC-REZ 250 68
USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY V V IVIDENSKA 1083 PRAHA 4 142 20

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bakardjiev, Mario Prague, CZ 1 1
Brynda, Jiri Prague, CZ 1 1
Cigler, Petr Prague, CZ 13 52
Dzubak, Petr Brodek u Prerova, CZ 11 2
Gruner, Bohumir Brandysek, CZ 2 1
Hajduch, Marian Moravsky Beraun, CZ 25 288
Holub, Josef Prague, CZ 2 3
Mader, Pavel Prague, CZ 1 1
Maloy, Rezacova Pavlina Velvary, CZ 1 1
Sicha, Vaclav Prague, CZ 1 1

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