Variant immunoglobulins with improved manufacturability

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United States of America Patent

PATENT NO 9290563
APP PUB NO 20150104449A1
SERIAL NO

14589066

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Abstract

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This invention relates to the modification of the amino acid sequence of an immunoglobulin molecule at certain key positions within regions of the VH and VL FR and CDR3 domains and/or the CH1 domain which are prone to aggregation. Immunoglobulins modified as described may display improved manufacturability, for example, reduced aggregation propensity and/or increased production levels.

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Patent Owner(s)

  • LONZA BIOLOGICS PLC

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Arnell, Andreas Newmarket, GB 2 0
Jimenez, Jose London, GB 30 113
Michael, Rebecca Cambridge, GB 4 18
Stallwood, Yvette Newmarket, GB 4 32
Zurdo, Jesus Cambridge, GB 12 34

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