METHODS OF PREPARING INTERMEDIATE OF FLUTICASONE PROPIONATE
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United States of America Patent
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Apr 5, 2016
Grant Date -
Apr 7, 2016
app pub date -
Apr 16, 2015
filing date -
Oct 3, 2014
priority date (Note) -
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Abstract
A method of preparing a thioic acid intermediate of fluticasone propionate includes: treating a 17β-[(N,N-dimethyl carbamoyl)thio]carbonyl compound in a solution including an alcohol and an alkali metal hydroxide, an alkaline-earth metal hydroxide, or a mixture thereof to cleave an amide from the 17β-[(N,N-dimethyl carbamoyl)thio]carbonyl compound; treating the solution to separate an aqueous portion; and adding an acid to the aqueous portion to obtain the thioic acid intermediate of fluticasone propionate. A method of preparing fluticasone propionate includes preparing the thioic acid intermediate of fluticasone propionate, and alkylating the thioic acid intermediate of fluticasone propionate to prepare the fluticasone propionate.
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