Method and device for genetic map construction, method and device for haplotype analysis

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United States of America Patent

PATENT NO 9309570
APP PUB NO 20140194300A1
SERIAL NO

14240955

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Abstract

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Provided are the method and device for genetic map construction and the method and device for haplotype determination of a single cell. Wherein the method for genetic map construction includes: whole genome sequencing for at least a single cell from a same species, aligning the sequencing data to reference sequences respectively to determine genotypes of SNP sites, determining male parent a/female parent b typing results of SNP genotypes of a single cell based on the genotypes of SNP sites, dividing the chromosome of the species into linkage regions based on the male parent a/female parent b typing results of SNP genotypes, determining the variation ratio of a/b between two linkage regions to obtain recombination rate between every two continuous linkage regions, determining recombination map of a single cell according to the recombination rate, wherein the boundary site of a and b is the recombination site, determining the recombination rate of each recombination rate based on the recombination map to construct a genetic map of the species.

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Patent Owner(s)

Patent OwnerAddress
BGI TECH SOLUTIONS CO LTD518083 1010 BUILDING 7 HUADA COMPREHENSIVE PARK 21 HONG'AN THIRD STREET YANTIAN STREET YANTIAN DISTRICT SHENZHEN GUANGDONG PROVINCE SHENZHEN CITY GUANGDONG PROVINCE 518083

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hou, Yong Shenzhen, CN 30 101
Liang, Shuheng Shenzhen, CN 1 10
Shao, Di Shenzhen, CN 2 10
Song, Luting Shenzhen, CN 1 10
Tao, Ye Shenzhen, CN 113 776
Wu, Kui Shenzhen, CN 35 145
Zheng, Zequn Shenzhen, CN 3 11
Zheng, Zhijun Shenzhen, CN 19 130

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