Compositions and methods for topical application and transdermal delivery of botulinum toxins
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United States of America Patent
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Apr 19, 2016
Grant Date -
Apr 2, 2009
app pub date -
Mar 3, 2006
filing date -
Mar 3, 2005
priority date (Note) -
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Abstract
Improved formulations for transdermal delivery of botulinum toxin are disclosed. The formulations include, for example, botulinum toxin non-covalently associated with a positively charged backbone having branching or efficiency groups. The formulations also include a partitioning agent, oligo-bridge, or polyanion bridge, and may optionally contain a viscosity modifying agent. The formulations are designed for topical application onto the skin of a patient and may be used to treat wrinkles, hyperhidrosis, and other health-related problems. Kits for administration are also described.
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