18F-labelled folates

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United States of America Patent

PATENT NO 9315506
SERIAL NO

12595301

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Abstract

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The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein the fluorine-18 is covalently linked to the aminobenzoyl moiety, which connects the condensed pyrimidine heterocycle to the amino acid portion within folate structures, as well as their precursors and their non-radioactive references, a method of their preparation, as well as their use in diagnosis of a cell or population of cells expressing a folate-receptor and monitoring of cancer and inflammatory and autoimmune diseases and therapy thereof.

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Patent Owner(s)

  • MERCK & CO., INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ametamey, Simon Mensah Zurich, CH 13 29
Groehn, Viola Dachsen, CH 48 142
Moser, Rudolf Schaffhausen, CH 61 293
Ross, Tobias Ludwig Zurich, CH 7 17

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