Method of selecting aptamers
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United States of America Patent
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Apr 19, 2016
Grant Date -
Dec 2, 2010
app pub date -
Oct 22, 2008
filing date -
Oct 22, 2007
priority date (Note) -
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Abstract
The present invention is a method for the identification of one or more aptamers to at least one target molecule, the method comprising: selecting candidate aptamer sequences that bind to a target molecule, assigning to the bound sequences a measure (fitness function) of each sequence's aptameric potential, allowing evolution of some or all of the sequences to create a new mixture of candidate sequences, and repeating the method with the newly created candidate aptamer pool until the aggregate aptameric potential of the candidate pool reaches a plateau, wherein sequences present in the final pool are optimal aptamers to the target molecule.
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