Microfluidic devices and methods of use in the formation and control of nanoreactors

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United States of America Patent

PATENT NO 9328344
APP PUB NO 20130217583A1
SERIAL NO

13759660

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Abstract

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The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label, thereby identifying a single compound from a library of compounds.

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Patent Owner(s)

  • RAINDANCE TECHNOLOGIES, INC.

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Boitard, Laurent Gullford, US 19 688
Branciforte, Jeffrey Cromwell, US 9 612
Charles, Yves Waterbury, US 8 609
Feke, Gilbert West Simsbury, US 26 739
Hinz, Wolfgang Guilford, US 172 15019
Link, Darren Lexington, US 21 3356
Lu, John Q Gullford, US 7 609
Marran, David Durham, US 55 4671
Rothberg, Jonathan M Guilford, US 554 35427
Tabatabai, Ahmadali Branford, US 7 609
Weiner, Michael Guilford, US 78 3765

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