Fibrin binding peptide conjugates for diagnostic and therapeutic applications
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United States of America Patent
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May 10, 2016
Grant Date -
Aug 12, 2010
app pub date -
Dec 11, 2007
filing date -
Dec 11, 2006
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Abstract
The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel peptides able to bind fibrin, to a process for their preparation and to compositions thereof for use in therapy and diagnostics. The compounds of the invention bind, in particular, to fibrin present in the extracellular matrix (EC) of tumor or connective tissue of stroma thus acting as targeting moieties able to bring and successfully bound an active moiety linked thereto to fibrin depositions inside solid tumors.
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