Diagnostic prediction of rheumatoid arthritis and systemic lupus erythematosus

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United States of America Patent

PATENT NO 9335329
APP PUB NO 20110311999A1
SERIAL NO

13141916

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention pertains to a diagnostic assay for the diagnosis of an autoimmune disease. The present invention provides an improved diagnostic assay for the diagnosis of an autoimmune disease, particularly rheumatoid arthritis (RA) and Systemic Lupus Erythematosus (SLE). In particular the invention pertains to a method of determining in a sample of a subject the presence of two or more antibodies comprising the step of determining whether an antibody is present in a sample that specifically recognizes a hnRNP-DL polypeptide or a fragment thereof or a splice variant thereof and the further step of determining whether at least one further antibody is present in the sample that specifically recognizes a at least one other hnRNP polypeptide which is not sequence homologue to said hnRNP-DL polypeptide or fragments thereof or splice variants thereof, and/or said CCP peptide and/or a polypeptide comprising at least the Fc-part of IgG, respectively. The invention also relates to polypeptides, protein sets and antibodies that may be used in such methods and assays and for therapeutic use in RA and SLE patients.

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Patent Owner(s)

  • MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V.;CHARITE-UNIVERSITATSMEDIZIN BERLIN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Konthur, Zoltán Berlin, DE 4 3
Lehrach, Hans Berlin, DE 36 257
Skriner, Karl Berlin, DE 12 4

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