IPNV-ISAV bivalent vaccine using a virus-like particle-based platform and methods of using the same

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United States of America Patent

PATENT NO 9345760
APP PUB NO 20140314858A1
SERIAL NO

14343666

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Abstract

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The present invention provides bivalent oral vaccines against infectious pancreatic necrosis virus (IPNV) and infectious salmon anemia virus (ISAV). Yeast cells comprise an expression vector comprising (i) a polynucleotide sequence encoding a VP2 capsid protein of IPNV and (ii) a polynucleotide sequence encoding one or more antigenic epitopes of hemaglutinin of ISAV. The yeast cells express sub-viral particles (SVP) comprising a VP2 capsid protein of IPNV and one or more antigenic epitopes of hemaglutinin of ISAV. The yeast cells and SVP may be administered in an effective amount to increase the amount of antibodies against IPNV and ISAV in the fish, preferably Salmonidae. The yeast cells and SVP may be in the form of fish food for administering to the fish orally.

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Patent Owner(s)

Patent OwnerAddress
ADVANCED BIONUTRITION CORPORATION7155 COLUMBIA GATEWAY DRIVE COLUMBIA MD 21046

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dhar, Arun K Sykesville, US 9 69

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