Synthesis of telaprevir and boceprevir, or pharmaceutically acceptable salts or solvates as well as intermediate products thereof including β-amino acids prepared via Mukaiyama aldol addition

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United States of America Patent

PATENT NO 9346853
APP PUB NO 20150183824A1
SERIAL NO

14408465

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Abstract

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The invention relates to synthetic routes for preparing telaprevir and boceprevir, and its intermediates as well as peptides other than telaprevir. The synthetic routes are based on a Mukaiyama aldol addition reaction of a silyl enol ether or an enolate with an imine. The invention also refers to novel intermediates for preparing telaprevir/boceprevir or other peptides.

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Patent Owner(s)

  • SANDOZ AG

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Benito-Garagorri, David Kundl, AT 1 0
Felzmann, Wolfgang Kundl, AT 8 5
Hoeferl-Prantz, Kathrin Kundl, AT 1 0
Wilhelm, Thorsten Kundl, AT 12 5

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