17-hydroxyprogesterone ester containing oral compositions and related methods

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United States of America Patent

PATENT NO 9364547
APP PUB NO 20140271882A1
SERIAL NO

14261057

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Abstract

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The present invention provides for bioavailable oral dosage forms containing esters of 17-hydroxyprogesterone as well as related methods. The oral dosage forms can be formulated for pregnancy support and can include a therapeutically effective amount of an ester of 17-hydroxyprogesterone and a pharmaceutically acceptable carrier. In another embodiment, a pharmaceutically acceptable oral dosage form for pregnancy support is provided. The pharmaceutically acceptable oral dosage can include a therapeutically effective amount of an ester of 17-hydroxyprogesterone and a pharmaceutically acceptable carrier. The oral dosage form can, when measured using a USP Type-II dissolution apparatus in 900 mL of deionized water with 0.5 (w/v) of sodium lauryl sulfate at 50 RPM at 37° C., release at least 20 wt % of the dose of the ester of 17-hydroxyprogesterone after 60 minutes, or in the alternative release at least 20 wt % more after 60 minutes than an equivalently dosed oral dosage form without the carrier.

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Patent Owner(s)

Patent OwnerAddress
LIPOCINE INC675 ARAPEEN DRIVE SUITE 202 SALT LAKE CITY UT 84108

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chickmath, Basawaraj Plymouth, US 47 774
Chidambaram, Nachiappan Sandy, US 128 837
Giliyar, Chandrashekar North Maple Grove, US 98 1872
Nachaegari, Satish Kumar Salt Lake City, US 46 546
Patel, Mahesh V Salt Lake City, US 171 9185
Venkateshwaran, Srinivasan Salt Lake City, US 88 3169

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