Compositions and methods for targeting stromal cells for the treatment of cancer

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United States of America Patent

PATENT NO 9365641
SERIAL NO

14042306

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Abstract

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The present invention provides compositions and methods for treating cancer in a human. The invention relates to targeting the stromal cell population in a tumor microenvironment. For example, in one embodiment, the invention provides a composition that is targeted to fibroblast activation protein (FAP). The invention includes a chimeric antigen receptor (CAR) which comprises an anti-FAP domain, a transmembrane domain, and a CD3zeta signaling domain.

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Patent Owner(s)

  • THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;THE WISTAR INSTITUTE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Albelda, Steven Philadelphia, US 16 79
June, Carl H Merion Station, US 203 7513
Pure, Ellen Bryn Mawr, US 3 73
Scholler, John Penn Valley, US 31 871
Wang, Liang-Chuan Philadelphia, US 10 82

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