High-throughput complement-mediated antibody-dependent and opsonic bactericidal assays

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United States of America Patent

PATENT NO 9365885
APP PUB NO 20110312510A1
SERIAL NO

12816534

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Abstract

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The disclosure provides methods and kits for performing automated high-throughput assays to measure bactericidal activity in samples, such as plasma or sera from vaccinated subjects to evaluate the efficacy of vaccines against bacterial pathogens. The method combines obligatory linear-range data analysis, plate sealing and liquid volume handling for all assay steps to provide an automated, high-throughput measurement of bactericidal activity with favorable inter-assay and inter-operator variability.

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Patent Owner(s)

  • SMITHKLINE BEECHAM BIOLOGICALS S.A.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Donnelly, John J Moraga, US 9 65
Janes, Jeffrey Eugene San Diego, US 1 27
Mak, Puiying Annie San Diego, US 1 27
Santos, George Wayland, US 2 31

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