Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
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United States of America Patent
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Jun 14, 2016
Grant Date -
Aug 8, 2013
app pub date -
Apr 12, 2013
filing date -
Nov 7, 2008
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Abstract
The invention is directed to methods of monitoring B-cell lymphoid proliferative disorders, such as B-cell acute lymphoblastic leukemias, by measuring the presence, absence and/or levels of correlating, or index, clonotypes and related clonotypes that have evolved therefrom, for example, as part of the disease condition. In one aspect, such methods are implemented by generating sequencing-based clonotype profiles and determining frequencies of correlating, or index, clonotypes present, including new clonotypes that have evolved therefrom, particularly, in the case of B-cell ALL, by VH substitution. The invention also includes use of such monitoring information to modify treatment status of a patient.
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