CA6 antigen-specific cytotoxic conjugate and methods of using the same

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United States of America Patent

PATENT NO 9370584
SERIAL NO

12912107

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Abstract

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Cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate are disclosed are all embodiments of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the CA6 glycotope. The present invention is also directed to humanized or resurfaced versions of DS6, an anti-CA6 murine monoclonal antibody, and epitope-binding fragments thereof.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chun, Philip Malden, US 7 89
Payne, Gillian Waban, US 28 457
Tavares, Daniel J Natick, US 23 321

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