Macrocyclic ghrelin receptor modulators and methods of using the same

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United States of America Patent

PATENT NO 9371297
SERIAL NO

12028611

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Abstract

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The present invention provides novel conformationally-defined macrocyclic compounds that can function as selective modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, central nervous system disorders, bone disorders, genetic disorders, hyperproliferative disorders and inflammatory disorders.

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Patent Owner(s)

Patent OwnerAddress
OCERA THERAPEUTICS INC525 UNIVERSITY AVENUE SUITE 610 PALO ALTO CA 94301

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Beauchemin, Sophie Sherbrooke, CA 10 100
Benakli, Kamel Bluebell, US 12 153
Brassard, Martin Sherbrooke, CA 2 47
Fraser, Graeme L Rixensart, BE 21 393
Hoveyda, Hamid Brussels, BE 28 180
Marsault, Eric Sherbrooke, CA 40 481
Oullet, Luc Sherbrooke, CA 3 0
Peterson, Mark L Sherbrooke, CA 31 629
Wang, Zhigang Montreal, CA 278 4608

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