Method of producing FR901228

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United States of America Patent

PATENT NO 9371361
APP PUB NO 20150225453A1
SERIAL NO

14692055

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Abstract

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Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion.

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Patent Owner(s)

Patent OwnerAddress
ASTELLAS PHARMA INCTOYKO

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Higaki, Tomoji Chuo-ku, JP 13 77
Kanda, Munekazu Chuo-ku, JP 10 71
Matsuda, Mitsunori Chuo-ku, JP 15 143
Tsuboi, Masaru Chuo-ku, JP 18 88
Ueda, Satoshi Chuo-ku, JP 268 3081
Watamoto, Yoko Chuo-ku, JP 10 71

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