Conjugation methods

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United States of America Patent

PATENT NO 9376500
SERIAL NO

14095579

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Abstract

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This invention describes a method of conjugating a cell binding agent such as an antibody with an effector group (e.g., a cytotoxic agent) or a reporter group (e.g., a radionuclide), whereby the reporter or effector group is first reacted with a bifunctional linker and the mixture is then used without purification for the conjugation reaction with the cell binding agent. The method described in this invention is advantageous for preparation of stably-linked conjugates of cell binding agents, such as antibodies with effector or reporter groups. This conjugation method provides in high yields conjugates of high purity and homogeneity that are without inter-chain cross-linking and inactivated linker residues.

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Patent Owner(s)

  • IMMUNOGEN, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chari, Ravi V J Newton, US 102 3814
Kellogg, Brenda A Medford, US 7 80
Singh, Rajeeva Framingham, US 33 733

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