Methods and compositions for the treatment of β-thalassemia

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United States of America Patent

PATENT NO 9377471
APP PUB NO 20150141341A1
SERIAL NO

14547208

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Abstract

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Methods and compositions for the treatment of β-thalassemia are provided. Methods and compositions restore or increase erythrocyte maturation in individuals afflicted with β-TM by preventing proteolysis of GATA-1 protein. Screening methods for identifying agents which bind heat shock protein 70 (HSP-70) and inhibit HSP-70 α-globin binding, but which allow GATA-1 protein-HSP-1 binding in a manner that prevents GATA-1 proteolysis.

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Patent Owner(s)

Patent OwnerAddress
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)3 RUE MICHEL-ANGE 75794 PARIS CEDEX 16
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)101 RUE DE TOLBIAC CEDEX 13 PARIS 75013
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS3 AVENUE VICTORIA PARIS 75004
FONDATION IMAGINE24 BOULEVARD DU MONTPARNASSE PARIS 75015
UNIVERSITE PARIS DESCARTES ? PARIS V12 RUE DE L'ECOLE DE MEDECINE PARIS 75006

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Arlet, Jean-Benoit Paris, FR 4 1
Courtois, Genevieve Paris, FR 3 1
Hermine, Olivier Paris, FR 35 115
Ribeil, Jean-Antoine Paris, FR 2 1

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