Cytotoxic benzodiazepine derivatives

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United States of America Patent

PATENT NO 9381256
SERIAL NO

14843604

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Abstract

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The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.

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Patent Owner(s)

Patent OwnerAddress
IMMUNOGEN INC830 WINTER STREET WALTHAM MA 02451

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chari, Ravi V J Newton, US 102 3831
Miller, Michael Louis Framingham, US 58 751
Shizuka, Manami Belmont, US 39 76

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