Small molecule inhibitors of nicotinamide phosphoribosyltransferase (NAMPT)

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United States of America Patent

PATENT NO 9382267
SERIAL NO

14361857

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Abstract

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The present invention relates to novel compounds, their use as anti-cancer agents and their synthesis. In particular, the compounds contain cluster boron moieties such as carborane or a borohydride and act as inhibitors for the enzyme Nampt. The biological properties of the inventive cluster boron compounds, in terms of biological inhibition and antiproliferative effect, are greater than other small molecule inhibitors of Nampt.

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Patent Owner(s)

Patent OwnerAddress
THE CURATORS OF THE UNIVERSITY OF MISSOURI316 UNIVERSITY HALL COLUMBIA MO 65211

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lee,, Jr Mark Wayne Columbia, US 1 2
Sevryugina, Yulia Columbia, US 4 3

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