JFH-1 based HCV cell culture systems for NS5A of genotypes 1-7
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United States of America Patent
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Jul 12, 2016
Grant Date -
Feb 28, 2013
app pub date -
Oct 1, 2010
filing date -
Oct 2, 2009
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Abstract
The present inventors developed hepatitis C virus recombinants expressing NS5A from genotype 1a, 1b, 2a, 3a, 4a, 5a, 6a or 7a in the context of a genotype 2a backbone. Additional recombinants express NS5A and the structural proteins (Core, E1 and E2), p7 and NS2 from genotype 1a, 1b, 3a, 4a, 5a, 6a or 7a in the genotype 2a backbone. Sequence analysis of the recombinants recovered after viral passage in Huh7.5 cells revealed adaptive mutations in NS5A and/or NS3. The importance of these mutations for improved growth kinetics was shown in reverse genetic studies.
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