Methods and compositions for inactivating glutamine synthetase gene expression

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United States of America Patent

PATENT NO 9388426
APP PUB NO 20150087067A1
SERIAL NO

14552174

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Abstract

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Disclosed herein are methods and compositions for inactivating a glutamine synthetase (GS) gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.

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Patent Owner(s)

  • SANGAMO BIOSCIENCES, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Liu, Pei-Qi Richmond, US 15 181
Miller, Jeffrey C Richmond, US 104 3609

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