FRET based multiplex probes

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United States of America Patent

PATENT NO 9388450
APP PUB NO 20140274797A1
SERIAL NO

14206738

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Abstract

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The present invention includes compositions and methods for fluorescence-based multiplex probe to simultaneously detect one or more enzymatic activities comprising: a first enzymatic target having a first end and a second end, wherein the first end of the first enzymatic target is attached to a central body and the second end of the first enzymatic target is attached to a first fluorophore; a second enzymatic target having a first end and a second end, wherein the first end of the second enzymatic target is attached to the central body and the second end of the second enzymatic target is attached to a third fluorophore; wherein the central body comprises at least one second fluorophore; wherein the first enzymatic target comprises a specific cleavage site of a first enzyme that cleaves the first enzymatic target; and wherein the second enzymatic target comprises a specific cleavage site of a second enzyme.

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Patent Owner(s)

Patent OwnerAddress
TEXAS CHRISTIAN UNIVERSITY2800 S UNIVERSITY DRIVE FORT WORTH TX 76129

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fudala, Rafal Fort Worth, US 2 0
Gryczynski, Ignacy Fort Worth, US 12 400
Gryczynski, Zygmunt Fort Worth, US 13 429
Maliwal, Badri P Fort Worth, US 7 904

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