Methods and materials for assessing loss of heterozygosity
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United States of America Patent
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Jul 12, 2016
Grant Date -
Jan 15, 2015
app pub date -
Jun 18, 2014
filing date -
Dec 21, 2011
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Abstract
This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.
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