Influenza hemagglutinin proteins and methods of use thereof

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United States of America Patent

PATENT NO 9393297
APP PUB NO 20150056233A1
SERIAL NO

14450236

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Abstract

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In some embodiments the present invention provides influenza hemagglutinin (“HA”) polypeptides, proteins, and protein complexes that comprise a stalk domain that is engineered to facilitate maintenance of its native trimeric conformation, even if the head domain of the HA protein is removed or disrupted. In some embodiments, the present invention provides compositions comprising such polypeptides, proteins, and protein complexes, and methods of use of such proteins and compositions, for example as vaccine immunogens.

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Patent Owner(s)

Patent OwnerAddress
CALDER BIOSCIENCES INC140 58TH STREET BUILDING A UNIT 8J NEW YORK NY 11220

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alff, Peter Joseph New York, US 7 31
Bertuccioli, Claudio New York, US 7 31
Marshall, Christopher Patrick New York, US 13 40
Yondola, Mark Andrew Medford, US 4 13

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