Method for constructing libraries of non-standard peptide compounds comprising N-methyl amino acids and other special (non-standard) amino acids and method for searching and identifying active species

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United States of America Patent

PATENT NO 9410148
APP PUB NO 20130178394A1
SERIAL NO

13821940

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Abstract

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A method for screening a non-standard peptide compound in the peptide library that binds to the target substance, comprising the steps: (i) preparing a non-standard peptide library wherein a special (non-standard) amino acid is randomly incorporated into the peptide sequence by a cell-free (in vitro) translation system comprising a tRNA acylated by a special (non-standard) amino acid; (ii) bringing the obtained peptide library in contact with a target substance; and (iii) selecting a non-standard peptide that binds to the target substance as an active peptide.

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Patent Owner(s)

Patent OwnerAddress
THE UNIVERSITY OF TOKYO3-1 HONGO 7-CHOME BUNKYO-KU TOKYO 113-8654

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Suga, Hiroaki Tokyo, JP 45 166
Yamagishi, Yusuke Tokyo, JP 13 111

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