Vanilloid fatty hydroxamates as therapeutic anti-inflammatory pharmaceuticals
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United States of America Patent
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Aug 23, 2016
Grant Date -
Oct 4, 2012
app pub date -
Mar 16, 2012
filing date -
Mar 16, 2011
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Abstract
Three unique subtypes of N-hydroxyamides and N-hydroxycarbamates containing both the vanilloid moiety (4-hydroxy-3-methoxybenzyl) and a lipophilic aliphatic moiety. Also disclosed are direct syntheses of these vanilloid fatty hydroxamates. The compounds possess inhibitory activity against the enzymes fatty acid amide hydrolase (FAAH) and matrix metallo-proteinase 9 (MMP-9). In addition, these substances bind to the calcium channel protein TRPV1 and inhibit vesicant-induced inflammation in skin and cornea. The compounds have utility in treating topical or systemic inflammatory processes in the skin and/or eye.
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