Activated nitric oxide donors and methods of making and using thereof

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 9439915
APP PUB NO 20150290224A1
SERIAL NO

14684793

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Abstract

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Described herein are compositions useful in anticancer treatment. The compositions are composed of (a) an O2-aryl substituted diazeniumdiolate and (b) an amphiphile, wherein the amount of amphiphile is sufficient to produce a liposome or micelle. The compositions described herein provide numerous advantages such as increased solubility and stability of the O2-aryl substituted diazeniumdiolate in vivo. The compositions also do not induce hypotension. Methods for using the compositions in anticancer treatment are also described herein.

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Patent Owner(s)

  • UNIVERSITY OF UTAH

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kosack, Ken M West Valley City, US 1 1
Shami, Paul J Sandy, US 4 5

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