Neuroprotection and myelin repair using nestorone®
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United States of America Patent
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Sep 20, 2016
Grant Date -
May 9, 2013
app pub date -
Dec 21, 2012
filing date -
Oct 19, 2009
priority date (Note) -
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Abstract
Methods for treating neurodegeneration and/or myelination in patients are disclosed comprising treating the patient with a progestin compound which exerts binding to progesterone receptors and elicits progesterone-receptor-induced biological responses without interacting with the androgen receptor and without inducing androgen or glucocorticoid biological responses at a dosage sufficient to prevent or reduce neurodegeneration. The progestin compound preferably comprises 16-methylene-17α-acetoxy-19-norpregn-4-ene-3,20-dione, and the methods include combining the progestin compound with an estrogen compound to provide both contraception and treatment for myelin repair and neurodegeneration, and include effects on stroke and TBI.
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