Method of preparing intermediate of salmeterol

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United States of America Patent

PATENT NO 9447067
SERIAL NO

14714196

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Abstract

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A method of preparing an intermediate of salmeterol (Compound 1, 2-amino-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol) includes: reacting compound 2 with 2-methoxypropene in a first organic solvent to produce a reaction solution including compound 3, compound 2 including a 2-bromo precursor of Compound 1; reacting compound 3 with a nitrogen source to produce compound 4; reacting compound 4 with sodium borohydride in a second organic solvent to produce compound 5; and debenzylating compound 5 by ammonium formate/palladium-carbon catalytic transfer hydrogenation in a third organic solvent to produce Compound 1. A method of preparing salmeterol includes preparing Compound 1, and reacting Compound 1 to prepare salmeterol.

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Patent Owner(s)

Patent OwnerAddress
AMPHASTAR NANJING PHARMACEUTICALS INCJIANGSU 210038

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Song Nanjing, CN 164 1006
Qiu, Yinhua Nanjing, CN 2 0
Wu, Zhengyuan Nanjing, CN 2 0
Zhang, Haoning Nanjing, CN 15 1

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