Sialic acid derivatives for protein derivatisation and conjugation

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United States of America Patent

PATENT NO 9452224
APP PUB NO 20140220046A1
SERIAL NO

14155855

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Abstract

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Derivatives are synthesized of starting materials, usually polysaccharides, having sialic acid at the reducing terminal end, in which the reducing terminal unit is transformed into an aldehyde group. Where the polysaccharide has a sialic acid unit at the non-reducing end it may be passivated, for instance by converting into hydroxyl-substituted moiety. The derivatives may be reacted with substrates, for instance containing amine or hydrazine groups, to form non-cross-linked polysialylated compounds. The substrates may, for instance, be therapeutically useful drugs peptides or proteins or drug delivery systems.

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Patent Owner(s)

Patent OwnerAddress
LIPOXEN TECHNOLOGIES LIMITEDLONDON BIOSCIENCE INNOVATION CENTRE 2 ROYAL COLLEGE STREET LONDON NW1 0NH

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gregoriadis, Gregory London, GB 52 366
Hreczuk-Hirst, Dale Howard London, GB 8 59
Jain, Sanjay London, GB 115 1620
Laing, Peter London, GB 67 450
Papaioannou, Ioannis London, GB 24 79

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