Cyclotides as immunosuppressive agents

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United States of America Patent

PATENT NO 9453052
SERIAL NO

14366427

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to a pharmaceutical composition comprising a cyclotide for use in immune suppression as well as to a method for immune suppression comprising the step of administering an effective amount of a pharmaceutical composition comprising such a cyclotide to a subject in need thereof. The present invention also relates to a pharmaceutical composition comprising a cyclotide for use in treating or preventing a disorder selected from the group consisting of (i) an autoimmune disorder; (ii) a hypersensitivity disorder; and (iii) a lymphocyte-mediated inflammation. Likewise, the present invention also relates to a method for treating or preventing a disorder selected from the group consisting of (i) an autoimmune disorder; (ii) a hypersensitivity disorder; and (iii) a lymphocyte-mediated inflammation. The present invention further relates to a method of screening for and/or selecting an immunosuppressive cyclotide or a mutation which results in a mutated cyclotide having an induced or enhanced immunosuppressive activity. The present invention further relates to a method of producing an immunosuppressive cyclotide or an immunosuppressive pharmaceutical composition. The present invention further relates to a mutated cyclotide having immunosuppressive activity and a pharmaceutical composition comprising the same.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITATSKLINIKUM FREIBURGHUGSTETTER STRASSE 49 FREIBURG D-79106

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gruber, Christian Werner Vienna, AT 3 6
Gruendemann, Carsten Freiburg, DE 3 6

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