Implantable drug delivery device with bladder retention feature
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United States of America Patent
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Oct 4, 2016
Grant Date -
Apr 12, 2012
app pub date -
Oct 6, 2011
filing date -
Oct 6, 2010
priority date (Note) -
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Abstract
Implantable devices and methods for controlled drug delivery are provided. The device includes a device structure deformable between a retention shape and a low profile shape for deployment in the bladder of a patient and has a drug reservoir lumen in which a drug formulation is housed. The device also includes a buoyancy retention portion, which includes a volume of entrapped air or a gas-generating or effervescent powder which will generate a volume of entrapped air following contact with urine in the bladder. The buoyancy retention portion may include a water permeable and/or biodegradable wall, which can release the entrapped air following drug release, to cause the device to sink into the bladder neck to facilitate device expulsion without the need for a device retrieval medical procedure.
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