Modified DNA-binding proteins and uses thereof

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United States of America Patent

PATENT NO 9458205
APP PUB NO 20130196373A1
SERIAL NO

13679684

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Abstract

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Disclosed herein are enhanced polypeptides, polynucleotides encoding these polypeptides, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.

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Patent Owner(s)

  • SANGAMO BIOSCIENCES, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gregory, Philip D Orinda, US 75 3071
Miller, Jeffrey C San Leandro, US 104 3649
Paschon, David Oakland, US 62 1913
Rebar, Edward J San Francisco, US 90 3914
Tan, Siyuan Lexington, US 29 1184
Urnov, Fyodor Richmond, US 106 4635
Zhang, Lei Davis, US 2499 17879

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