Antibody induced cell membrane wounding

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 9458241
APP PUB NO 20130164283A1
SERIAL NO

13770619

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Abstract

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Compositions and methods for inducing cell membrane wounding, cell permeabilization and cell killing are provided. The composition comprises a polyvalent agent that binds to a highly expressed cell surface antigen present on the surface of a cell. Preferably, the cell surface antigen is associated with the cytoskeleton of the cell. A preferred polyvalent agent is an IgM, and enhanced cell wounding and killing can be provided by the addition of a crosslinking agent. At sublethal concentrations in vivo, the cell wounding antibodies permeabilize cells and dramatically enhance response to chemotherapeutic agents, even in patients refractory to the chemotherapeutic agents.

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Patent Owner(s)

  • IGM BISOSCIENCES A/S;THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bhat, Neelima M Los Altos, US 9 317
Bieber, Marcia M Los Altos, US 8 242
Sanders, Martin E Hillsborough, US 77 939
Teng, Nelson N H Hillsborough, US 17 492

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