Adeno-associated virus virions with variant capsid and methods of use thereof

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United States of America Patent

PATENT NO 9458517
APP PUB NO 20150232953A1
SERIAL NO

14701063

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Abstract

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The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells, when administered via intravitreal injection, compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.

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Patent Owner(s)

Patent OwnerAddress
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA1111 FRANKLIN STREET TWELFTH FLOOR OAKLAND CA 94607-5200

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Byrne, Leah C T Berkeley, US 7 197
Dalkara, Mourot Deniz Berkeley, US 9 476
Flannery, John G Berkeley, US 26 706
Klimczak, Ryan R San Francisco, US 13 623
Koerber, James T San Francisco, US 27 668
Schaffer, David V Danville, US 64 1196
Visel, Meike El Cerrito, US 16 482

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