Glycopeptide analyzer

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United States of America Patent

PATENT NO 9460903
APP PUB NO 20150144783A1
SERIAL NO

14553311

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Abstract

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The same sample S is analyzed using an ion-trap (IT) mass spectrometer section 11 in which ions are captured in an ion trap before mass spectrometry and a time-of-flight (TOF) mass spectrometer section 12 in which ions generated from the sample are directly subjected to mass spectrometry. A mass spectrum creator 21 creates an IT mass spectrum and a TOF mass spectrum from the measured results. A glycopeptide detector 23 detects fragment ion peaks related to neutral loss of sugars from the IT mass spectrum as well as peaks corresponding to intact molecular ions from the TOF mass spectrum, and furthermore, detects peaks common to the two spectra as glycopeptide ions. A quantitative analyzer 24 determines relative quantities of glycoforms of the glycopeptide based on the TOF mass spectrum. A structural analyzer 25 analyzes the structure of the glycopeptide using the result of an MSn analysis of the sample S.

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Patent Owner(s)

Patent OwnerAddress
SHIMADZU CORPORATION1 NISHINOKYO KUWABARA-CHO NAKAGYO-KU KYOTO-SHI KYOTO 6048511 ?6048511

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Murase, Masaki Nagoya, JP 50 203

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