Modified protozoan expressing at least two variable surface proteins (VSP), a vaccine comprising it and procedures, uses, and methods thereof

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United States of America Patent

PATENT NO 9463229
SERIAL NO

13132468

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Abstract

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Modified protozoa parasites comprising simultaneous expression on its surface of at least two variable surface proteins (VSP). The modified protozoa may also simultaneously express the complete repertoire of variable surface proteins. Protozoa show reduced expression of Dicer, RNA-dependant RNA-polymerase (RdRP) enzymes or both, wherein the RdRP gene and/or the Dicer gene has been silenced. The protozoan may be any protozoan showing an antigenic variation mechanism.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSIDAD CATOLICA DE CORDOBACALLE OBISPO TREJO 323 CORDOBA 5000

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lujan, Hugo Daniel Córdoba, AR 1 0

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