Substituted pyrrolo[2,3-D]dipyrimidines for selectively targeting tumor cells with FR-alpha and FR-beta type receptors

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United States of America Patent

PATENT NO 9481678
APP PUB NO 20160229857A1
SERIAL NO

14617332

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Abstract

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Pyrrolo[2,3-d]pyrimidine derivatives, and pharmaceutical acceptable salts thereof, useful in therapeutically treating patients with cancer are disclosed. These compounds selectively target folate receptors (FR) of cancerous tumor cells and inhibit purine synthesis and hence, DNA synthesis.

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Patent Owner(s)

Patent OwnerAddress
WAYNE STATE UNIVERSITY656 W KIRBY FAB DETROIT MI 48202
DUQUESNE UNIVERSITY OF THE HOLY GHOST600 FORBES AVENUE PITTSBURGH PA 15282

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gangjee, Aleem Allison Park, US 99 435
Matherly, Larry H Novi, US 19 40

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