PPS for the prevention of potential adverse effects caused by CD3 specific binding domains

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 9486475
APP PUB NO 20140228316A1
SERIAL NO

14176089

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

The present invention relates to a pentosanpolysulfate (PPS) or a pharmaceutically acceptable salt thereof for use in the amelioration, treatment, or prevention of adverse neurological events caused by administering an antibody or fragment thereof comprising a CD3 binding domain, including a CD19 x CD3 bispecific single chain antibody, such as blinatumomab. PPS is a semi-synthetically produced heparin-like macromolecular carbohydrate derivative, which chemically and structurally resembles glycosaminoglycans. Kits comprising a PPS, an antibody or fragment thereof comprising a CD3 binding domain, and instructions for administration, which indicate that the PPS is to be employed for the amelioration, treatment or prevention of adverse neurological events caused by administering the antibody or fragment thereof comprising said CD3 binding domain, are also disclosed.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddress
AMGEN RESEARCH (MUNICH) GMBH81477 MÜNCHEN

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dopfer, Elaine-Pashupati Munich, DE 4 41
Hoffmann, Patrick Bad Heilbrunn, DE 69 1097
Klinger, Matthias Gilching, DE 27 546
Kufer, Peter Munich, DE 106 2671
Naegele, Virginie Munich, DE 5 17
Nagorsen, Dirk Munich, DE 16 72
Scheele, Juergen Munich, DE 22 132
Zugmaier, Gerhard Munich, DE 21 209

Cited Art Landscape

Load Citation

Patent Citation Ranking

Forward Cite Landscape

Load Citation

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
11.5 Year Payment $7400.00 $3700.00 $1850.00 May 8, 2028
Fee Large entity fee small entity fee micro entity fee
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00