Process for preparation of montelukast sodium

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United States of America Patent

PATENT NO 9487487
APP PUB NO 20150299127A1
SERIAL NO

14395368

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Abstract

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Disclosed is a process for the preparation of montelukast sodium. The process comprises a) reacting 2-(2-(3(S)-(3-(2-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-hydroxypropyl)phenyl)-2-propanol with methane sulfonyl chloride and coupling the resultant mesylate compound with 1-(mercaptomethyl)cyclopropane acetic acid in presence of a base and free alkali source followed by saltification with an amine in a single step reaction and b) converting the montelukast amine salt to montelukast sodium salt.

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Patent Owner(s)

Patent OwnerAddress
LAURUS LABS LIMITED500078 SHAREERPET HYDERABAD

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chava, Satyanarayana Hyderabad, IN 38 17
Gorantla, Seeta R Hyderabad, IN 7 4
Indukuri, Venkata S Hyderabad, IN 8 4
Mohammad, Yaseen Hyderabad, IN 2 1
Simhadri, Srinivas Hyderabad, IN 6 5

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