N-terminal derivatisation of proteins with polysaccharides

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United States of America Patent

PATENT NO 9492556
SERIAL NO

14614406

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Abstract

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The present invention relates to methods for producing N-terminal derivatives of proteins in which a polysaccharide, preferably having at least terminal sialic units, and preferably consisting essentially only of sialic acid units, is reacted at the N-terminus of a protein or peptide under controlled conditions to produce an N-terminal derivative. The controlled conditions include use of acidic pH for the derivatization step and a higher pH for purification. The derivatives are useful for improving pharmacokinetics and pharmacodynamics of proteins and peptides.

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Patent Owner(s)

Patent OwnerAddress
LIPOXEN TECHNOLOGIES LIMITEDLONDON BIOSCIENCE INNOVATION CENTRE 2 ROYAL COLLEGE STREET LONDON NW1 0NH

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gregoriadis, Gregory London, GB 52 366
Jain, Sanjay London, GB 115 1620
Laing, Peter London, GB 67 450

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