TIMP3 as VEGF inhibitor

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United States of America Patent

PATENT NO 9498509
SERIAL NO

11653647

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Abstract

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Polypeptides or proteins comprising tissue inhibitor of mettaloproteinases-3 (TIMP3) or variants of TIMP3 can be used to substantially inhibit vascular endothelial growth factor (VEGF) binding to VEGF receptor-2 (VEGFR2/KDR/Flk-1)) without substantially inhibiting VEGF binding to VEGF receptor 1 (VEGFR1/Flt-1).

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Patent Owner(s)

  • THE CLEVELAND CLINIC FOUNDATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Anand-Apte, Bela Shaker Heights, US 7 8

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