Non-hemolytic LLO fusion proteins and methods of utilizing same

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United States of America Patent

PATENT NO 9499602
SERIAL NO

14163269

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Abstract

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The present invention provides recombinant proteins or peptides comprising a mutated listeriolysin O (LLO) protein or fragment thereof, comprising a substitution or internal deletion of the cholesterol-binding domain or a portion thereof, fusion proteins or peptides comprising same, nucleotide molecules encoding same, and vaccine vectors comprising or encoding same. The present invention also provides methods of utilizing recombinant proteins, peptides, nucleotide molecules, and vaccine vectors of the present invention to induce an immune response to a peptide of interest.

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Patent Owner(s)

Patent OwnerAddress
TO THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA3160 CHESTNUT STREET SUITE 200 CENTER FOR TECHNOLOGY TRANSFER PHILADELPHIA PA 19104-6283

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
MaCiag, Paulo Long Grove, US 14 338
Paterson, Yvonne Philadelphia, US 59 1982

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