Methods for inhibiting the binding of endosialin to ligands

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United States of America Patent

PATENT NO 9505842
SERIAL NO

14509353

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Abstract

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The invention provides methods for inhibiting the interaction of endosialin with endosialin ligands. The inhibition is effectuated on the genetic level, by inhibiting endosialin gene expression, and on the protein level, by blocking the interaction of cell-surface expressed endosialin with ligands such as fibronectin and collagen. The invention provides methods for identifying inhibitors of the interaction of endosialin with endosialin ligands. Also provided are methods for inhibiting angiogenesis and neovascularization in vivo and in vitro.

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Patent Owner(s)

Patent OwnerAddress
EISAI INC10 TICE BOULEVARD WOODCLIFF LAKE NJ 07677

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Grasso, Luigi Bryn Mawr, US 100 824
Nicolaides, Nicholas C Glen Mills, US 115 999
Sass, Philip M Audubon, US 80 760
Tomkowicz, Brian East Norriton, US 6 15
Zhou, Yuhong Phoenixville, US 30 117

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